As an editor of technical materials, I can totally relate to this article on copyediting.com titled, How to Edit Topics You're Clueless About which is all about, you guessed it, how to edit topics you know nothing about. Yes, it can be done.
In my early days of editing, I proofed and edited college papers, a master's thesis in nuclear engineering something or other, and annual reports and grants for a research center. Fast-forward to today where I read resumes full of technical computer terminology. It can be done and I really do enjoy it.
If you're looking for a website that gets you -- and your struggles and joys with editing -- check out more great articles on copyediting.com. You won't be disappointed!